The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest. We introduce the concept of an 'ecosystem' consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact - all of which must work synergistically. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Optical coherence tomography (OCT) is the most recent addition to this pantheon. Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. > Thickening of the fovea with markedly decreased optical reflectivity in mostly the outer. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. optical reflectivity throughout the whole layer of the retina.

OCT fills the gap between ultrasound and confocal microscopy, since it has a higher resolution than ultrasound and a higher penetration than confocal. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function - diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography (OCT) is a noninvasive optical imaging modality providing real-time video rate images in two and three dimensions of biological tissues with micrometer resolution. Using the rich information the book is replete with, a wide range of readers, from scientists and physicists to engineers as well as biomedical and clinical researchers, can get a handle on the latest major advances in FF-OCM.This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. The last part of the book provides an overview of possible applications of FF-OCM in medicine, biology, and materials science.Ī comprehensive compilation of self-contained chapters written by leading experts, this handbook is a definitive guide to the theoretical analyses, technological developments, and applications of FF-OCM. Extensions of FF-OCM for image contrast enhancement or functional imaging are reported in part III. The main technological developments of FF-OCM for improving the image acquisition speed and for endoscopic imaging are presented in part II. By providing unparalleled capability to differentiate individual plexus layers in the retina, OCTA has demonstrated its excellence in clinical management of diabetic. After a general introduction to FF-OCM, the fundamental characteristics of the technology are analyzed and discussed theoretically. As a new optical coherence tomography (OCT) modality, OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. It is organized into four parts with a total of 21 chapters written by recognized experts and major contributors to the field. Optical coherence tomography (OCT) 1 and its Doppler variants, optical Doppler tomography (ODT) 2 or color Doppler optical coherence tomography (CDOCT) 3, are analogous to ultrasound imaging where light is used instead of sound.

This handbook is the first to be entirely devoted to FF-OCM. The technique can be employed in diverse applications, in particular for noninvasive examination of biological tissues. FF-OCM benefits from the lateral imaging resolution of optical microscopy along with the capacity of optical axial sectioning at micrometer-scale resolution. The technology is based on low-coherence interference microscopy, which uses an area camera for en face imaging of the full-field illuminated object. OCT performs optical ranging in tissue and is analogous to ultrasound except reflections of near-infrared light are detected rather than. Full-field optical coherence microscopy (FF-OCM) is an imaging technique that provides cross-sectional views of the subsurface microstructure of semitransparent objects. Optical coherence tomography (OCT) is an emerging high-resolution biomedical imaging technology that for larger and undifferentiated cells can perform cellular-level imaging at the expense of imaging depth.

Handbook optical coherence tomography